Beth (Lauren German), Lorna (Heather Matarazzo) and Whitney (Bijou Phillips), three young American women traveling abroad in Rome, decide to take a weekend excursion. Lured from their intended destination by a beautiful acquaintance (Vera Jordanova), the women anticipate a stay at a luxurious spa. Instead, they become pawns in a grisly game designed to entertain wealthy deviants from around the world.